Experimental Pyelonephritis v. Susceptibility of Rats to Hematogenous Pyelonephritis Following Chemical Injury of the Kidneys †
نویسندگان
چکیده
Renal infection rarely occurs following the intravenous injection of Gramnegative bacilli into normal animals. If, however, the kidney has been damaged by either direct trauma or ureteral ligation, an increased susceptibility to infection can be demonstrated."' In this regard, studies have shown that the location of the site of injury within the kidney is important in determining alterations of host resistance. While multiple cortical lesions did not predispose the kidney to hematogenous infection, a single medullary scar resulted in anatomical and functional changes which permitted the multiplication of bacteria and resultant infection in the involved segment of tissue.' This differential effect of localized injury suggested a study of several chemicals which are known to damage particular segments of the nephron. Mercuric chloride, which primarily causes necrosis of cells of the proximal convoluted tubules:' and not the collecting tubules and a sulfonamide derivative, sodium N'-acetyl-sulfathiazole, which produces along with some cortical damage obstruction of the collecting tubules by intraluminal crystallization and precipitation"6 were administered to rats prior to bacterial injection. The results obtained indicate that while injury to the nephron excluding the collecting system did not affect susceptibility to hematogenous infection, intrarenal obstruction at the level of the larger collecting tubules did have that effect.
منابع مشابه
The Effect of Diethylstilbestrol on the Susceptibility of Rats to Hematogenous Pyelonephritis.
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 32 شماره
صفحات -
تاریخ انتشار 1959